Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFA<i>lin</i>-Modified Peptidic Radioligands Targeting Both Integrin α_vβ₃ and the MC1 Receptor-Suitable for the Specific Visualization of Melanomas?

• Main Authors: Xia Cheng (Author), Ralph Hübner (Author), Valeska von Kiedrowski (Author), Gert Fricker (Author), Ralf Schirrmacher (Author), Carmen Wängler (Author), Björn Wängler (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combining two peptides addressing two different receptors to a heterobivalent peptidic ligand (HBPL) is thought to enable an improved tumor-targeting sensitivity and thus tumor visualization, compared to monovalent peptide ligands. In the case of melanoma, the Melanocortin-1 receptor (MC1R), which i...