Colonic Hydrogen Sulfide-Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Cav3.2 and TRPA1 Channels in Mice

• Hoofdauteurs: Maho Tsubota-Matsunami (Auteur), Yumi Noguchi (Auteur), Yasumasa Okawa (Auteur), Fumiko Sekiguchi (Auteur), Atsufumi Kawabata (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2012-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Luminal hydrogen sulfide (H2S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca2+ channels. Here we analyzed the mechanisms for H2S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H2S donor, evoke...