Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to be a potential platform f...

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Main Authors: Joanna Małolepsza (Author), Aleksandra Marchwicka (Author), Remigiusz A. Serwa (Author), Sanna P. Niinivehmas (Author), Olli T. Pentikäinen (Author), Edyta Gendaszewska-Darmach (Author), Katarzyna M. Błażewska (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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