Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars

• Main Authors: Masayo Aoki (Author), Noriko M. Matsumoto (Author), Teruyuki Dohi (Author), Hiroaki Kuwahawa (Author), Satoshi Akaishi (Author), Yuri Okubo (Author), Rei Ogawa (Author), Hirofumi Yamamoto (Author), Kazuaki Takabe (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypertrophic scars (HSs) and keloids are histologically characterized by excessive extracellular matrix (ECM) deposition. ECM deposition depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs). TIMP-1 has been linked to ECM degradation and is...