Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

• मुख्य लेखकों: Mai Takahashi (लेखक), Kenji Mizumura (लेखक), Yasuhiro Gon (लेखक), Tetsuo Shimizu (लेखक), Yutaka Kozu (लेखक), Sotaro Shikano (लेखक), Yuko Iida (लेखक), Mari Hikichi (लेखक), Shinichi Okamoto (लेखक), Kota Tsuya (लेखक), Asami Fukuda (लेखक), Shiho Yamada (लेखक), Kaori Soda (लेखक), Shu Hashimoto (लेखक), Shuichiro Maruoka (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence of cigarette smoke (CS) exposure. Moreover, smoking deposits iron in the mitochondria of alveolar epithelial cells. Iron overload...