Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

• Main Authors: Mai Takahashi (Author), Kenji Mizumura (Author), Yasuhiro Gon (Author), Tetsuo Shimizu (Author), Yutaka Kozu (Author), Sotaro Shikano (Author), Yuko Iida (Author), Mari Hikichi (Author), Shinichi Okamoto (Author), Kota Tsuya (Author), Asami Fukuda (Author), Shiho Yamada (Author), Kaori Soda (Author), Shu Hashimoto (Author), Shuichiro Maruoka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence of cigarette smoke (CS) exposure. Moreover, smoking deposits iron in the mitochondria of alveolar epithelial cells. Iron overload...