Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads

• Main Authors: Emma L. Gunderson (Author), Clifford Bryant (Author), Christina A. Bulman (Author), Chelsea Fischer (Author), Mona Luo (Author), Ian Vogel (Author), Kee-Chong Lim (Author), Shabnam Jawahar (Author), Nancy Tricoche (Author), Denis Voronin (Author), Christopher Corbo (Author), Rene B. Ayiseh (Author), Faustin P. T. Manfo (Author), Glory E. Mbah (Author), Fidelis Cho-Ngwa (Author), Brenda Beerntsen (Author), Adam R. Renslo (Author), Sara Lustigman (Author), Judy A. Sakanari (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped reduce infection rates and thus prevent transmission...