Design, Synthesis and Biological Evaluation of New 5,5-Diarylhydantoin Derivatives as Selective Cyclooxygenase-2 Inhibitors

A new group of 5,5-diarylhydantoin derivatives bearing a methylsulfonyl COX-2 pharmacophore at the para position of the C-5 phenyl ring were designed and synthesized as selective COX-2 inhibitors. In vitro COX-1/COX-2 inhibition structure-activity relationships identified 5-[4-(methylsulfonyl)phenyl...

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Main Authors: Afshin ZARGHI (Author), Farin SATTARY JAVID (Author), Razieh GHODSI (Author), Orkideh G. DADRASS (Author), Bahram DARAEI (Author), Mehdi HEDAYATI (Author)
Format: Book
Published: MDPI AG, 2011-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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