Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

• Main Authors: Bárbara Velame Ferreira Teixeira (Author), André Lacerda Braga Teles (Author), Suellen Gonçalves da Silva (Author), Camila Carane Bitencourt Brito (Author), Humberto Fonseca de Freitas (Author), Acássia Benjamim Leal Pires (Author), Thamires Quadros Froes (Author), Marcelo Santos Castilho (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate syn...