Covariate modeling in pharmacometrics: General points for consideration

• Main Authors: Kinjal Sanghavi (Author), Jakob Ribbing (Author), James A. Rogers (Author), Mariam A. Ahmed (Author), Mats O. Karlsson (Author), Nick Holford (Author), Estelle Chasseloup (Author), Malidi Ahamadi (Author), Kenneth G. Kowalski (Author), Susan Cole (Author), Essam Kerwash (Author), Janet R. Wade (Author), Chao Liu (Author), Yaning Wang (Author), Mirjam N. Trame (Author), Hao Zhu (Author), Justin J. Wilkins (Author), for the ISoP Standards & Best Practices Committee (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Modeling the relationships between covariates and pharmacometric model parameters is a central feature of pharmacometric analyses. The information obtained from covariate modeling may be used for dose selection, dose individualization, or the planning of clinical studies in different popula...