Current strategies for the design of PROTAC linkers: a critical review

PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an "anchor" to bind to an E3 ubiquitin ligase and a "warhead" to bind to a protein of interest, connected by a chemical linker. Targeted protein degradation by PROTACs has emerged...

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Bibliographic Details
Main Authors: Robert I. Troup (Author), Charlene Fallan (Author), Matthias G. J. Baud (Author)
Format: Book
Published: Open Exploration Publishing Inc., 2020-10-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available