Current strategies for the design of PROTAC linkers: a critical review

• मुख्य लेखकों: Robert I. Troup (लेखक), Charlene Fallan (लेखक), Matthias G. J. Baud (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Open Exploration Publishing Inc., 2020-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an "anchor" to bind to an E3 ubiquitin ligase and a "warhead" to bind to a protein of interest, connected by a chemical linker. Targeted protein degradation by PROTACs has emerged...