Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

• Main Authors: Qing Zhang (Author), Agnès Duplany (Author), Vincent Moncollin (Author), Sandrine Mouradian (Author), Evelyne Goillot (Author), Laetitia Mazelin (Author), Karine Gauthier (Author), Nathalie Streichenberger (Author), Céline Angleraux (Author), Jie Chen (Author), Shuzhe Ding (Author), Laurent Schaeffer (Author), Yann‐Gaël Gangloff (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related...