Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

• Main Authors: Anne-Sophie Rebstock (Author), Mareike Wiedmann (Author), Beatrix Stelte-Ludwig (Author), Harvey Wong (Author), Amy J. Johnson (Author), Raquel Izumi (Author), Ahmed Hamdy (Author), Hans-Georg Lerchen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The development of bioconjugates for the targeted delivery of anticancer agents is gaining momentum after recent success of antibody drug conjugates (ADCs) in the clinic. Smaller format conjugates may have several advantages including better tumor penetration; however, cellular uptake...