Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

• Autores principales: Kristoffer L. Egerod (Autor), Natalia Petersen (Autor), Pascal N. Timshel (Autor), Jens C. Rekling (Autor), Yibing Wang (Autor), Qinghua Liu (Autor), Thue W. Schwartz (Autor), Laurent Gautron (Autor)
• Formato: Libro
• Publicado: Elsevier, 2018-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objectives: G protein-coupled receptors (GPCRs) act as transmembrane molecular sensors of neurotransmitters, hormones, nutrients, and metabolites. Because unmyelinated vagal afferents richly innervate the gastrointestinal mucosa, gut-derived molecules may directly modulate the activity of vagal affe...