Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

• Main Authors: Kristoffer L. Egerod (Author), Natalia Petersen (Author), Pascal N. Timshel (Author), Jens C. Rekling (Author), Yibing Wang (Author), Qinghua Liu (Author), Thue W. Schwartz (Author), Laurent Gautron (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: G protein-coupled receptors (GPCRs) act as transmembrane molecular sensors of neurotransmitters, hormones, nutrients, and metabolites. Because unmyelinated vagal afferents richly innervate the gastrointestinal mucosa, gut-derived molecules may directly modulate the activity of vagal affe...