Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines

• Main Authors: Shixia Wang (Author), Te-hui Chou (Author), Anthony Hackett (Author), Veronica Efros (Author), Yan Wang (Author), Dong Han (Author), Aaron Wallace (Author), Yuxin Chen (Author), Guangnan Hu (Author), Shuying Liu (Author), Paul Clapham (Author), James Arthos (Author), David Montefiori (Author), Shan Lu (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Our previous preclinical studies and a Phase I clinical trial DP6-001 have indicated that a polyvalent Env formulation was able to elicit broadly reactive antibody responses including low titer neutralizing antibody responses against viral isolates of subtypes A, B, C and AE. In the current report,...