The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

• Hoofdauteurs: Emiliana Echeverría (Auteur), Maia Cabrera (Auteur), Valeria Burghi (Auteur), Máximo Sosa (Auteur), Sonia Ripoll (Auteur), Agustín Yaneff (Auteur), Federico Monczor (Auteur), Carlos Davio (Auteur), Carina Shayo (Auteur), Natalia Fernández (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...