The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

• Váldodahkkit: Emiliana Echeverría (Dahkki), Maia Cabrera (Dahkki), Valeria Burghi (Dahkki), Máximo Sosa (Dahkki), Sonia Ripoll (Dahkki), Agustín Yaneff (Dahkki), Federico Monczor (Dahkki), Carlos Davio (Dahkki), Carina Shayo (Dahkki), Natalia Fernández (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...