The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

• Asıl Yazarlar: Emiliana Echeverría (Yazar), Maia Cabrera (Yazar), Valeria Burghi (Yazar), Máximo Sosa (Yazar), Sonia Ripoll (Yazar), Agustín Yaneff (Yazar), Federico Monczor (Yazar), Carlos Davio (Yazar), Carina Shayo (Yazar), Natalia Fernández (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...