The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

• Main Authors: Emiliana Echeverría (Author), Maia Cabrera (Author), Valeria Burghi (Author), Máximo Sosa (Author), Sonia Ripoll (Author), Agustín Yaneff (Author), Federico Monczor (Author), Carlos Davio (Author), Carina Shayo (Author), Natalia Fernández (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...