Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy

• Main Authors: Wen Zhu (Author), Yang Wang (Author), Liangyin Lv (Author), Hui Wang (Author), Wenqiang Shi (Author), Zexin Liu (Author), Mingzhe Zhou (Author), Jianwei Zhu (Author), Huili Lu (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developing universal CARs with improved flexible targeting and controllable activities is urgently needed. While several studies have suggested the potential of CD16a in tandem with monoclonal antibodies to construct universal CAR-T cells, the weak affinity between them is one of the limiting factor...