Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy

• मुख्य लेखकों: Wen Zhu (लेखक), Yang Wang (लेखक), Liangyin Lv (लेखक), Hui Wang (लेखक), Wenqiang Shi (लेखक), Zexin Liu (लेखक), Mingzhe Zhou (लेखक), Jianwei Zhu (लेखक), Huili Lu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Developing universal CARs with improved flexible targeting and controllable activities is urgently needed. While several studies have suggested the potential of CD16a in tandem with monoclonal antibodies to construct universal CAR-T cells, the weak affinity between them is one of the limiting factor...