Synthesis and Structure-Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-<i>N</i>-(Pyridin-2-ylmethyl)Pyrazolo[1,5-<i>a</i>]Pyrimidin-7-Amines

• Main Authors: Hamish S. Sutherland (Author), Peter J. Choi (Author), Guo-Liang Lu (Author), Anna C. Giddens (Author), Amy S. T. Tong (Author), Scott G. Franzblau (Author), Christopher B. Cooper (Author), Brian D. Palmer (Author), William A. Denny (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyrazolo[1,5-<i>a</i>]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-&l...