Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy

• Egile Nagusiak: Chuanmin Zhang (Egilea), Yinan Zhao (Egilea), Enxia Zhang (Egilea), Meilin Jiang (Egilea), Defu Zhi (Egilea), Huiying Chen (Egilea), Shaohui Cui (Egilea), Yuhong Zhen (Egilea), Jingnan Cui (Egilea), Shubiao Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The combination of chemotherapeutic drug paclitaxel (PTX) and VEGF siRNA could inhibit cancer development with synergistic efficacy. However, efficient and safe delivery systems with high encapsulation efficiency of PTX and a long-time release of drugs are urgently needed. In this study, novel nanop...