Metopimazine is primarily metabolized by a liver amidase in humans

• Main Authors: Robert W. Busby (Author), Xiaokun Cai (Author), Sihyung Yang (Author), Luis Ramos (Author), Lata Venkatarangan (Author), Helen Shen (Author), Stephen Wax (Author), Abu J. M. Sadeque (Author), Cyril De Colle (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Metopimazine (MPZ) is a peripherally restricted, dopamine D2 receptor antagonist used for four decades to treat acute nausea and vomiting. MPZ is currently under clinical investigation for the treatment of gastroparesis (GP). MPZ undergoes high first‐pass metabolism that produces metopimazi...