Autocrine Acetylcholine, Induced by IL-17A via NFκB and ERK1/2 Pathway Activation, Promotes MUC5AC and IL-8 Synthesis in Bronchial Epithelial Cells

• Main Authors: Angela Marina Montalbano (Author), Giusy Daniela Albano (Author), Anna Bonanno (Author), Loredana Riccobono (Author), Caterina Di Sano (Author), Maria Ferraro (Author), Liboria Siena (Author), Giulia Anzalone (Author), Rosalia Gagliardo (Author), Michael Paul Pieper (Author), Mark Gjomarkaj (Author), Mirella Profita (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-17A is overexpressed in the lung during acute neutrophilic inflammation. Acetylcholine (ACh) increases IL-8 and Muc5AC production in airway epithelial cells. We aimed to characterize the involvement of nonneuronal components of cholinergic system on IL-8 and Muc5AC production in bronchial epithel...