Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease

• Hauptverfasser: Ryan Morrow (Verfasst von), Ryan Funk (Verfasst von), Mara Becker (Verfasst von), Ashley Sherman (Verfasst von), Leon Van Haandel (Verfasst von), Taina Hudson (Verfasst von), Rebecca Casini (Verfasst von), Valentina Shakhnovich (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-05-01T00:00:00Z.
• Schlagworte: article
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Inside cells, the immunomodulator methotrexate (MTX) undergoes the addition of glutamates to form methotrexate polyglutamates (MTX-Glu)-promising biomarkers of systemic exposure and treatment response to MTX in rheumatology. MTX-Glu are underexplored in Inflammatory Bowel Disease (IBD), with no data...