The persistent inhibitory properties of saxagliptin on renal dipeptidyl peptidase-4: Studies with HK-2 cells in vitro and normal rats in vivo

• Main Authors: Masako Uchii (Author), Mariko Sakai (Author), Yuhei Hotta (Author), Satoshi Saeki (Author), Naoya Kimoto (Author), Akinori Hamaguchi (Author), Tetsuya Kitayama (Author), Shunji Kunori (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic study using normal rats. In HK-2 cells, the inhibit...