The persistent inhibitory properties of saxagliptin on renal dipeptidyl peptidase-4: Studies with HK-2 cells in vitro and normal rats in vivo

• Autores principales: Masako Uchii (Autor), Mariko Sakai (Autor), Yuhei Hotta (Autor), Satoshi Saeki (Autor), Naoya Kimoto (Autor), Akinori Hamaguchi (Autor), Tetsuya Kitayama (Autor), Shunji Kunori (Autor)
• Formato: Libro
• Publicado: Elsevier, 2017-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic study using normal rats. In HK-2 cells, the inhibit...