Effect of itraconazole on the safety and pharmacokinetics of antitumor SHR6390

The experimental drug SHR6390 has anti-tumor activity as a cyclin dependent kinase 4/6 inhibitor and is metabolized primarily by the cytochrome P450 3A4 enzyme. Therefore, The purpose of this trial was to evaluate the safety and pharmacokinetics of SHR6390, a potent cytochrome P450 3A4 inhibitor, in...

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Main Authors: Xiaozhi Lv (Author), Junyan Wu (Author), Herui Yao (Author), Suiwen Ye (Author), Nan Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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