Production of Knockout Mice using CRISPR/Cas9 in FVB Strain
KO mice provide an excellent tool to determine roles of specific genes in biomedical filed. Traditionally, knockout mice were generated by homologous recombination in embryonic stem cells. Recently, engineered nucleases, such as zinc finger nuclease, transcription activator-like effector nuclease an...
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The Korean Society of Animal Reproduction and Biotechnology,
2015-12-01T00:00:00Z.
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