Comparative pharmacokinetics of polymyxin B in critically ill elderly patients with extensively drug-resistant gram-negative bacteria infections

• Main Authors: Juan Zeng (Author), Bing Leng (Author), Xiaoyan Guan (Author), Shuangyan Jiang (Author), Maoyu Xie (Author), Wenying Zhu (Author), Yue Tang (Author), Lin Zhang (Author), Jing Sha (Author), Tengfei Wang (Author), Min Ding (Author), Nan Guo (Author), Jinjiao Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Elderly patients are more prone to develop acute kidney injury during infections and polymyxin B (PMB)-associated nephrotoxicity than young patients. The differential response to PMB between the elderly and young critically ill patients is unknown. We aimed to assess PMB exposure in el...