Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function

• Main Authors: Mégane A. Poncin (Author), Pierre Van Meerbeeck (Author), Joshua D. Simpson (Author), André Clippe (Author), François Tyckaert (Author), Fabrice Bouillenne (Author), Hervé Degand (Author), André Matagne (Author), Pierre Morsomme (Author), Bernard Knoops (Author), David Alsteens (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human peroxiredoxin-5 (PRDX5) is a unique redox-sensitive protein that plays a dual role in brain ischemia-reperfusion injury. While intracellular PRDX5 has been reported to act as a neuroprotective antioxidative enzyme by scavenging peroxides, once released extracellularly from necrotic brain cells...