Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples

• Main Authors: Pavol Kosik (Author), Matus Durdik (Author), Milan Skorvaga (Author), Daniela Klimova (Author), Dominika Kochanova (Author), Zlatica Cerna (Author), Miroslav Kubes (Author), Marek Holop (Author), Igor Belyaev (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preleukemic fusion genes (PFGs) occurring after DNA damage in hematopoietic stem progenitor cells (HSPCs) in utero often represent the initial event in the development of childhood leukemia. While the incidence of PFGs characteristic for acute lymphoblastic leukemia (ALL) was relatively well examine...