Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice

• Main Authors: Lei Wang (Author), Sai P. Pydi (Author), Yinghong Cui (Author), Lu Zhu (Author), Jaroslawna Meister (Author), Oksana Gavrilova (Author), Rebecca Berdeaux (Author), Jean-Philippe Fortin (Author), Kendra K. Bence (Author), Cecile Vernochet (Author), Jürgen Wess (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Given the worldwide epidemics of obesity and type 2 diabetes, novel antidiabetic and appetite-suppressing drugs are urgently needed. Adipocytes play a central role in the regulation of whole-body glucose and energy homeostasis. The goal of this study was to examine the metabolic effects o...