Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

• Main Authors: Xiaojin Chen (Author), Tao Guo (Author), Kaikai Zhang (Author), Jiacai Chen (Author), Caifen Wang (Author), Xiaohong Ren (Author), Qin Wang (Author), Yingchao Yang (Author), Chongjing Liu (Author), Wen Tan (Author), Shuangying Gui (Author), Li Wu (Author), Jiwen Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.5...