Inhibition of UV-Induced Stress Signaling and Inflammatory Responses in SKH-1 Mouse Skin by Topical Small-Molecule PD-L1 Blockade

• Principais autores: Sally E. Dickinson (Autor), Prajakta Vaishampayan (Autor), Jana Jandova (Autor), Yuchen (Ella) (Autor), Viktoria Kirschnerova (Autor), Tianshun Zhang (Autor), Valerie Calvert (Autor), Emanuel Petricoin, III (Autor), H-H. Sherry Chow (Autor), Chengcheng Hu (Autor), Denise Roe (Autor), Ann Bode (Autor), Clara Curiel-Lewandrowski (Autor), Georg T. Wondrak (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2024-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The immune checkpoint ligand PD-L1 has emerged as a molecular target for skin cancer therapy and might also hold promise for preventive intervention targeting solar UV light-induced skin damage. In this study, we have explored the role of PD-L1 in acute keratinocytic photodamage testing the effects...