Inhibition of UV-Induced Stress Signaling and Inflammatory Responses in SKH-1 Mouse Skin by Topical Small-Molecule PD-L1 Blockade

• Main Authors: Sally E. Dickinson (Author), Prajakta Vaishampayan (Author), Jana Jandova (Author), Yuchen (Ella) (Author), Viktoria Kirschnerova (Author), Tianshun Zhang (Author), Valerie Calvert (Author), Emanuel Petricoin, III (Author), H-H. Sherry Chow (Author), Chengcheng Hu (Author), Denise Roe (Author), Ann Bode (Author), Clara Curiel-Lewandrowski (Author), Georg T. Wondrak (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immune checkpoint ligand PD-L1 has emerged as a molecular target for skin cancer therapy and might also hold promise for preventive intervention targeting solar UV light-induced skin damage. In this study, we have explored the role of PD-L1 in acute keratinocytic photodamage testing the effects...