Is It Possible to Separate the Graft-Versus-Leukemia (GVL) Effect Against B Cell Acute Lymphoblastic Leukemia From Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplant?

• Auteurs principaux: Jacob Rozmus (Auteur), Sima T. Bhatt (Auteur), Nataliya Prokopenko Buxbaum (Auteur), Geoffrey D. E. Cuvelier (Auteur), Amanda M. Li (Auteur), Carrie L. Kitko (Auteur), Kirk R. Schultz (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Hematopoietic cell transplant is a curative therapy for many pediatric patients with high risk acute lymphoblastic leukemia. Its therapeutic mechanism is primarily based on the generation of an alloreactive graft-versus-leukemia effect that can eliminate residual leukemia cells thus preventing relap...