2-Deoxystreptamine Conjugates by Truncation-Derivatization of Neomycin

• Main Authors: Floris L. van Delft (Author), Floris P.J.T. Rutjes (Author), Gerard W. Canters (Author), Alessio Andreoni (Author), Leandro C. Tabares (Author), M. Waqar Aslam (Author)
• Format: Book
• Published: MDPI AG, 2010-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity w...