Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach

• Asıl Yazarlar: Jorge Alberto Valle da Silva (Yazar), Eugenie Nepovimova (Yazar), Teodorico Castro Ramalho (Yazar), Kamil Kuca (Yazar), Tanos Celmar Costa França (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed with the purpose of being a prophylactic reac...