Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and pazopanib eye‐drops among rats, rabbits and monkeys

• Main Authors: Shinya Horita (Author), Miwa Watanabe (Author), Mai Katagiri (Author), Hiroaki Nakamura (Author), Hiroki Haniuda (Author), Tomoyuki Nakazato (Author), Yoshiyuki Kagawa (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Age‐related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years. Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor (VEGF) plays a causal role in the formation of CNV. Alth...