Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and pazopanib eye‐drops among rats, rabbits and monkeys

• Главные авторы: Shinya Horita (Автор), Miwa Watanabe (Автор), Mai Katagiri (Автор), Hiroaki Nakamura (Автор), Hiroki Haniuda (Автор), Tomoyuki Nakazato (Автор), Yoshiyuki Kagawa (Автор)
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• Опубликовано: Wiley, 2019-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Age‐related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years. Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor (VEGF) plays a causal role in the formation of CNV. Alth...