Bioluminescent imaging of Trypanosoma brucei shows preferential testis dissemination which may hamper drug efficacy in sleeping sickness.

• Prif Awduron: Filip Claes (Awdur), Suman K Vodnala (Awdur), Nick van Reet (Awdur), Nathalie Boucher (Awdur), Hilda Lunden-Miguel (Awdur), Theo Baltz (Awdur), Bruno Maria Goddeeris (Awdur), Philippe Büscher (Awdur), Martin E Rottenberg (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Monitoring Trypanosoma spread using real-time imaging in vivo provides a fast method to evaluate parasite distribution especially in immunoprivileged locations. Here, we generated monomorphic and pleomorphic recombinant Trypanosoma brucei expressing the Renilla luciferase. In vitro luciferase activi...