Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies

• Main Authors: Fawaz E. Alanazi (Author), Homood M. As Sobeai (Author), Khalid Alhazzani (Author), Abdullah Al-Dhfyan (Author), Musaad A Alshammari (Author), Moureq Alotaibi (Author), Khaled Al-hosaini (Author), Hesham M. Korashy (Author), Ali Alhoshani (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. Metformin shows anti-tumor activities in several cancer types. How...