A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain

• Main Authors: Gyun Jee Song (Author), Md Habibur Rahman (Author), Mithilesh Kumar Jha (Author), Deepak Prasad Gupta (Author), Sung Hee Park (Author), Jae-Hong Kim (Author), Sun-Hwa Lee (Author), In-Kyu Lee (Author), Taebo Sim (Author), Yong Chul Bae (Author), Won-Ha Lee (Author), Kyoungho Suk (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GNF-2 is an allosteric inhibitor of Bcr-Abl. It was developed as a new class of anti-cancer drug to treat resistant chronic myelogenous leukemia. Recent studies suggest that c-Abl inhibition would provide a neuroprotective effect in animal models of Parkinson's disease as well as in clinical tr...