Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life?

• Main Authors: Quentin Allard (Author), Zoubir Djerada (Author), Claire Pouplard (Author), Yohann Repessé (Author), Dominique Desprez (Author), Hubert Galinat (Author), Birgit Frotscher (Author), Claire Berger (Author), Annie Harroche (Author), Anne Ryman (Author), Claire Flaujac (Author), Pierre Chamouni (Author), Benoît Guillet (Author), Fabienne Volot (Author), Jean Szymezak (Author), Philippe Nguyen (Author), Yoann Cazaubon (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model for eight factors VIII (FVIII) that could estimate individual PK parameters for target...