Hematopoietic Stem Cell Transplantation and Vasculopathy Associated With STAT3-Dominant-Negative Hyper-IgE Syndrome

• প্রধান লেখক: Mark J. Ponsford (Author), James Clark (Author), Joel Mock (Author), Mario Abinun (Author), Emily Carne (Author), Tariq El-Shanawany (Author), Paul E. Williams (Author), Anirban Choudhury (Author), Alexandra F. Freeman (Author), Andrew R. Gennery (Author), Stephen Jolles (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Dominant negative mutations in the transcription-factor STAT3 underlie the rare primary immunodeficiency Job's syndrome. Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) has shown promise in correction of the underlying immunological defect, with one report suggesting HSCT can prevent...