Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis.

• Main Authors: Sebastian Ziewer (Author), Marc P Hübner (Author), Bettina Dubben (Author), Wolfgang H Hoffmann (Author), Odile Bain (Author), Coralie Martin (Author), Achim Hoerauf (Author), Sabine Specht (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Lymphatic filariasis and onchocerciasis are two chronic diseases mediated by parasitic filarial worms causing long term disability and massive socioeconomic problems. Filariae are transmitted by blood-feeding mosquitoes that take up the first stage larvae from an infec...