Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis

• Hlavní autoři: Ray W. Chui (Autor), Joel Baublits (Autor), Fiona A. Chandra (Autor), Zack W. Jones (Autor), Michael J. Engwall (Autor), Hugo M. Vargas (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2021-11-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the potential for delayed ventricular repolarization and is a core safety assay mentioned in International Conference on Harmonization (ICH) S7B guideline. The typical telemetry study involves a dose‐r...