Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis

• Asıl Yazarlar: Ray W. Chui (Yazar), Joel Baublits (Yazar), Fiona A. Chandra (Yazar), Zack W. Jones (Yazar), Michael J. Engwall (Yazar), Hugo M. Vargas (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2021-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the potential for delayed ventricular repolarization and is a core safety assay mentioned in International Conference on Harmonization (ICH) S7B guideline. The typical telemetry study involves a dose‐r...