Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

• Main Authors: Jie Du (Author), Xiaodong Chen (Author), Yongshun Zhao (Author), Tingting Zhao (Author), Dalong Wang (Author), Zujia Chen (Author), Changyuan Wang (Author), Qiang Meng (Author), Jialin Yao (Author), Huijun Sun (Author), Kexin Liu (Author), Jingjing Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity. Sesame is a common medicine and food resource; its component lignans possess various pharmacological activities. In this study, the...