Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation

Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation

In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(l-lactide) (PLA) microspheres containing ibuprofen were prepared with the aim of prolonging the drug release. The oil-in-water (O/W) emulsion solvent evaporation technique was used, varying the polymer ratio. All formulations pr...

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Main Authors: Giovana Carolina Bazzo (Author), Aline Teixeira de Macedo (Author), Janine Paula Crenca (Author), Virgínia Emiliana Silva (Author), Eduardo Manoel Pereira (Author), Melissa Zétola (Author), Bianca Ramos Pezzini (Author)
Format: Book
Published: Universidade de São Paulo, 2012-12-01T00:00:00Z.
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3rd Floor Main Library

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