Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K+ Channels in β Cells

• Main Authors: Zhihong Liu (Author), Huanhuan Yang (Author), Linping Zhi (Author), Huan Xue (Author), Zhihong Lu (Author), Yanli Zhao (Author), Lijuan Cui (Author), Tao Liu (Author), Shouan Ren (Author), Peifeng He (Author), Yunfeng Liu (Author), Yi Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies suggest that Sphingosine 1-phosphate (S1P) plays an important role in regulating glucose metabolism in type 2 diabetes. However, its effects and mechanisms of promoting insulin secretion remain largely unknown. Here, we found that S1P treatment decreased blood glucose level and increa...