LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB

• Main Authors: Yuki Kawaguchi (Author), Junpei Matsubayashi (Author), Yutaka Kawakami (Author), Ryohei Nishida (Author), Yuji Kurihara (Author), Kohtaro Takei (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide but has no effective treatment. Amyloid beta (Aβ) protein, a primary risk factor for AD, accumulates and aggregates in the brain of patients with AD. Paired immunoglobulin-like receptor B (PirB)...