Recent Advances in Cancer Drug Discovery Through the Use of Phenotypic Reporter Systems, Connectivity Mapping, and Pooled CRISPR Screening

• Главные авторы: Natasha Salame (Автор), Katharine Fooks (Автор), Nehme El-Hachem (Автор), Jean-Pierre Bikorimana (Автор), François E. Mercier (Автор), Moutih Rafei (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Multi-omic approaches offer an unprecedented overview of the development, plasticity, and resistance of cancer. However, the translation from anti-cancer compounds identified in vitro to clinically active drugs have a notoriously low success rate. Here, we review how technical advances in cell cultu...