Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

• Main Authors: Haiming Xiao (Author), Xiaohong Sun (Author), Zeyuan Lin (Author), Yan Yang (Author), Meng Zhang (Author), Zhanchi Xu (Author), Peiqing Liu (Author), Zhongqiu Liu (Author), Heqing Huang (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes. Progestin and adipoQ receptor 3 (PAQR3), a key regulator of inflammation and metabolism, can negatively regulate the PI3K/AKT signaling pathway. Here, we report that gentiopicroside (GPS), the mai...