Detoxifying enzymes at the cross-roads of inflammation, oxidative stress and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

• Hauptverfasser: Francisco J Sánchez-Gómez (Verfasst von), Beatriz Díez-Dacal (Verfasst von), Elena García-Martín (Verfasst von), José A G Agúndez (Verfasst von), Maria Angeles Pajares (Verfasst von), Dolores Pérez-Sala (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Phase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging tha...