Carvacrol inhibits the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.3, Nav1.7, and Nav1.8 expressed in Xenopus oocytes with different potencies

• Main Authors: Takafumi Horishita (Author), Yuichi Ogata (Author), Reiko Horishita (Author), Ryo Fukui (Author), Kuniaki Moriwaki (Author), Susumu Ueno (Author), Nobuyuki Yanagihara (Author), Yasuhito Uezono (Author), Yuka Sudo (Author), Kouichiro Minami (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carvacrol is the predominant monoterpene in essential oils from many aromatic plants. Several animal studies showing analgesic effects of carvacrol indicate potential of carvacrol as a new medication for patients with refractory pain. Voltage-gated sodium channels (Nav) are thought to have crucial r...