Effects of Angiotensin II AT1-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats

• Main Authors: Shinji Kosaka (Author), Nicolas Pelisch (Author), Matlubur Rahman (Author), Daisuke Nakano (Author), Hirofumi Hitomi (Author), Hiroyuki Kobori (Author), Noriyasu Fukuoka (Author), Hideki Kobara (Author), Hirohito Mori (Author), Tsutomu Masaki (Author), Ludek Cervenka (Author), Yasuo Matsumura (Author), Hitoshi Houchi (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effects of angiotensin II AT1-receptor blockade with olmesartan on high fat (HF) diet-induced vascular oxidative stress and endothelial dysfunction in normal salt (NS) diet-fed Dahl salt-sensitive (DSS) rats. Treatment with NS + HF diet (32% crude fat, 0.3% NaCl) for 20 weeks signifi...